Stanton, B, et al., Fatty Acid Metabolism in Neonatal Chickens (Gallus Domesticus) Treated with 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (Tcdd) or 3,3',4,4',5-Pentachlorobiphenyl (Pcb-126) in Ovo. Comp Biochem Physiol C Toxicol Pharmacol, 2003. 136(1): 73-84.


Treatment of chickens as pre-incubation embryos with TCDD or PCB-126 altered fatty acid concentrations in their plasma 21 days later, compared with their oil vehicles (sunflower and corn oils, respectively). TCDD increased the concentrations of total fatty acids, lipid classes (phospholipids and cholesterol ester), fatty acid families (saturated, n-7 and n-6), and many specific fatty acids. The only fatty acid concentrations decreased by TCDD treatment were those of cholesterol ester fatty acids 20:3n3 and 24:6n3 and overall plasma 24:6n3. In contrast, PCB-126 treatment decreased total phospholipid, saturated and plasmogen fatty acid concentrations with generally decreasing trends in specific fatty acid concentrations. However, both TCDD and PCB-126 treatments increased total 22:1n9 and decreased 24:6n3 concentrations compared with their respective vehicles. The potential relationship between those fatty acid concentrations altered by toxicant treatment and alterations in brain symmetry was then examined using correlation analysis. Several fatty acid concentrations were significantly correlated with differences in brain morphology between the right and left hemispheres and these potential associations were different between toxicant and vehicle. 2003 Elsevier Inc. All rights reserved.

Asymmetry; Bird; Cholesterol ester; Development; Egg; Lipids; Phospholipid; Triacylglyceride

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